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| Letrozole |
| Letrozole is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer.
Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production. |
| Product Reference ID: MA-MK-1014-D |
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| Chemical Name: |
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile |
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| Description |
| CAS number |
112809-51-5 |
| Synonym |
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile |
| Molecular Formula |
C17H11N5 |
| Molecular Weight |
285.303 |
| Specifications |
USP |
| Packing |
Export worthy packing |
| Application |
For treatment of hormonally-responsive breast cancer. |
Material Safety Data Sheet
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Available on request
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| Availability |
For your requirements of evaluation, Pilots and Commercial procurement |
| Drug Master File |
Available |
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 Are you looking for Letrozole Intermediates ? Please click here to browse through the list of Letrozole Intermediates available with us. |
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NOTE: 
- Manus Aktteva Biopharma LLP, India is successfully representing suppliers, manufacturers from INDIA, suppliers, manufacturers from CHINA, and fulfilling the requirements of buyers from EUROPE, USA, South America, Japan, Korea, Taiwan, Australia, & middle-east.
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- Please note that products falling in to controlled substance category shall be exported directly from the manufacturer principals only against receipt of original import permission issued by concerned authorities of the importing country.
PATENTS:
- => Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
=> Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1)
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